Folate (Vitamin B9) is an essential nutrient that plays a vital role in mental health. Proper Folate metabolism is important in depression as it is involved in the synthesis and regulation of neurotransmitters in the brain, including serotonin, dopamine, and norepinephrine. These neurotransmitters play a critical role in mood regulation.
Folate receptor autoantibodies may interfere with folate transport to the brain in certain individuals. Studies have identified that these autoantibodies are present in a subset of individuals with depressive symptoms